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BCH80001 Biochemistry | The Role of P53 in Genome Integrity and Cancer

The role of p53 in genome integrity and cancer. The assignment must address the following:

(i) Detailed structure of the p53 protein and its various domains and their roles.
 
(ii) Its diverse functions in the cell, including its interactions with other proteins and the significance of these: give several examples.
 
(iii) A brief justification of why it is often called the ‘guardian of the genome’.
 
(iv) Relevance of loss of expression or other changes in p53 functionality to cancers.
 
(v) Any ethical/ legal/ social benefits as well as concerns related to the genetic testing for this gene.

(vi) The essay must use journal articles and not copy information from the textbook.

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