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BIOL122 : Human Biological Science 2 : Healthy and Non-Diabetic

1. The following physiological processes are important for blood glucose control:
• Insulin synthesis and release
• Insulin binding to target tissues
Explain how they are different in your person/client in comparison to a healthy non-diabetic person.
2. The following are some consequences of long-term poorly controlled hyperglycaemia:
• Neuropathy
• Myocardial infarction
Explain why they may occur in your person/client.
3. The following drugs are used in the management of type II diabetes mellitus.
• Metformin
• Insulin
Choose ONE that is appropriate for your person/client. Discuss why it can be used by your person/client by referring to its mechanism of action.

(a) Insulin resistance can occur in a person with increased abdominal adiposity. Explain the pathophysiological basis for this.
(b) Explain why HbA1c is used a measure of long-term control of blood glucose levels and how this measure will be useful in the management of your person’s/client’s disease.

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